Nurse Veronica Callahan (Taylor Schilling "Dark Matter") has just returned to Mercy Hospital from a tour in Iraq and knows more about medicine than all of the residents combined.
Together with fellow nurses Sonia Jimenez (Jaime Lee Kirchner, "Rescue Me"), who turns the heads of everyone in the hospital and Chloe Payne (Michelle Trachtenberg, "Gossip Girl"), a naïve newcomer who learns to deal with the difficulties of working in a challenging and sometimes unsettling profession, they navigate the daily traumas and social landmines of life and love both inside the hospital and out in the real world.
The cast also includes James Tupper ("Men in Trees") as Dr. Chris Sands, a new doctor at the hospital who complicates Veronica's life, Diego Klattenhoff ("Supernatural") as Mike Callahan, Veronica’s estranged husband, Guillermo Diaz ("Weeds") as Nurse Angel Lopez and James Le Gros as Dr. Harris ("Ally McBeal").